ABSTRACT
Objective@#To establish a method for determination of lead and istope ratios in the blood by ISIS-ICP-MS.@*Methods@#After wet digestion, the blood sample was on-line addition of thallium as internal standard and analyzed by ISIS-ICP-MS.@*Results@#The limit of detection was 0.03 μg/L and the lower limit of quantification was 0.08 μg/L. The detection concentration was 0.45 μg/L and the minimum quantitative concentration was 1.49 μg/L. The relative standard deviations (RSD) were 0.3%~1.7%. The recovery was between 91.0% and 103.4%. The precision of the major lead isotope ratios was better than 0.3%. The calibrated isotope ratios of the standard liquid are close to the certificate.@*Conclusion@#The method has a low detection limit, good precision and high accuracy, it is feasible for determination of lead concentration and isotope ratios in the bloune.